1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Nelonicline citrate

Nelonicline citrate (Synonyms: ABT-126 citrate)

Cat. No.: HY-16748A
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Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease.

For research use only. We do not sell to patients.

Nelonicline citrate Chemical Structure

Nelonicline citrate Chemical Structure

CAS No. : 1026136-84-4

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Description

Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (Ki=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease[1][2][3].

In Vitro

Nelonicline citrate is an agonist that binds with high affinity to α7 nAChRs in human brain (Ki= 12.3 nM) and activates currents in Xenopus oocytes expressing recombinant human α7 nAChRs (EC50=2 μM; intrinsic activity of 74% relative to acetylcholine). Nelonicline citrate does bind to α3β4* nAChRs in human IMR-32 neuroblastoma cells (Ki=60 nM), but has only 12% efficacy at 100,000 nM in a calcium flux assay in these cell. Like some other α7 nAChR agonists, Nelonicline citrate is also a 5-HT3 receptor antagonist, but it has >10-fold lower affinity for this receptor than for α7 nAChRs (Ki of 140 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

505.54

Formula

C₂₃H₂₇N₃O₈S

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Nelonicline citrate
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HY-16748A
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