2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues HIF/HIF Prolyl-Hydroxylase
  4. NEO-811

NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. NEO-811 is mediated by CRL4-CRBN E3 ligase for ARNT degradation. NEO-811 can be used for the study of clear cell renal cell carcinoma (ccRCC).

For research use only. We do not sell to patients.

NEO-811

NEO-811 Chemical Structure

CAS No. : 3084635-77-5

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Based on 1 publication(s) in Google Scholar

NEO-811 Related Antibodies

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HIF-1α HIF

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Description

NEO-811 is a selective and orally active ARNT (HIF-1β) molecular glue degrader. NEO-811 is mediated by CRL4-CRBN E3 ligase for ARNT degradation. NEO-811 can be used for the study of clear cell renal cell carcinoma (ccRCC)[1][2].

IC50 & Target

HIF-1β

 

In Vitro

NEO-811 is highly selective and does not degrade well-known neosubstrates. Transcriptomic profiling of NEO-811 activity across several VHL-deficient ccRCC cell lines confirmed suppression of HIF-2α target genes, including cyclin D and vascular endothelial growth factor (VEGF). NEO-811 also uniquely suppresses expression of target genes regulated by other Class I bHLH-PAS transcription factors, including HIF-1α and aryl hydrocarbon receptor (AHR). NEO-811 retaines activity in HIF-2α inhibitor-resistant cells that harbored previously described mutations[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NEO-811 Related Antibodies
Clinical Trial
Molecular Weight

543.59

Formula

C30H30FN5O4
CAS No.
SMILES

O=C1CCC(C2=CN=C(C=CC([C@@]3(O)CCN(CC4=CC=C(C5=NOC=N5)C=C4)CC3(C)C)=C6F)C6=C2)C(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NEO-811 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NEO-8113084635-77-5NEO811NEO 811Molecular GluesHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHARNT molecular glue degraderclear cell renal cell carcinoma (ccRCC)Inhibitorinhibitorinhibit

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