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Cat. No.: HY-111071R

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Nilofabicin (Standard)

(Synonyms: CG-400549 (Standard))

Nilofabicin (Standard) is an analytical standard for Nilofabicin (HY-111071). This product is intended for research and analytical applications. Nilofabicin (CG-400549) is an anti-bacterialagent that targets FabI. Nilofabicin shows high selectivity for the genus Staphylococcus and weak activity against most Gram-negative bacteria. Nilofabicin inhibits bacterial fatty acid biosynthesis, blocks phospholipid synthesis, and disrupts the structure of bacterial cell membranes. Nilofabicin exhibits in vivo antibacterial efficacy in a mouse model of systemic Staphylococcus aureus infection. Nilofabicin can be used in studies related to bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 934628-27-0
Formula: C₁₉H₂₀N₂O₂S
Molecular Weight:340.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nilofabicin (Standard) Chemical Structure

CAS No.: 934628-27-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 934628-27-0
Molecular Weight 340.44
Formula C₁₉H₂₀N₂O₂S
SMILES

O=C1C=C(OCCC2=CC=CS2)C=CN1CC3=CC=CC(N)=C3C
Synonyms

CG-400549 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Kim BY, et al. Solid state of CG-400549, a novel FabI inhibitor: characterization, dissolution, transformation. Archives of pharmacal research. 2011 May;34(5):775-9. [Content Brief]

[2]. Douglas EJA, et al. Novel antimicrobial strategies to treat multi-drug resistant Staphylococcus aureus infections. Microbial biotechnology. 2023 Jul;16(7):1456-1474. [Content Brief]

[3]. Wang J, et al. Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs. Future medicinal chemistry. 2012 Jun;4(9):1113-51. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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