BPH-715
Based on 1 Customer Validation
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC50 of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 1059677-23-4
- Formula: C17H31NO7P2
- Molecular Weight:423.38
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Parasite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
10 μM
Compound: BPH-715
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Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
Antimalarial activity against Plasmodium berghei NK65 infected in human HepG2 cells after 48 hrs by RT-PCR
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[PMID: 20457823] |
| MDA-MB-231 | IC50 |
100 nM
Compound: BPH-715
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Growth inhibition of human MDA-MB-231 cells
Growth inhibition of human MDA-MB-231 cells
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[PMID: 21780776] |
Chemical Information
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CAS No. 1059677-23-4
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Appearance Solid
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Molecular Weight 423.38
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Formula C17H31NO7P2
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Color White to off-white
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SMILES
CCCCCCCCCCOC1=C[N+](CC(P(O)(O)=O)P(O)([O-])=O)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
0.5 M NaOH : 80 mg/mL (188.96 mM; ultrasonic and adjust pH to 11 with NaOH)
DMSO : 5 mg/mL (11.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 0.5 M NaOH | 1 mM | 2.3619 mL | 11.8097 mL | 23.6194 mL | 59.0486 mL |
| 5 mM | 0.4724 mL | 2.3619 mL | 4.7239 mL | 11.8097 mL | |
| 10 mM | 0.2362 mL | 1.1810 mL | 2.3619 mL | 5.9049 mL | |
| 0.5 M NaOH | 15 mM | 0.1575 mL | 0.7873 mL | 1.5746 mL | 3.9366 mL |
| 20 mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.9524 mL | |
| 25 mM | 0.0945 mL | 0.4724 mL | 0.9448 mL | 2.3619 mL | |
| 30 mM | 0.0787 mL | 0.3937 mL | 0.7873 mL | 1.9683 mL | |
| 40 mM | 0.0590 mL | 0.2952 mL | 0.5905 mL | 1.4762 mL | |
| 50 mM | 0.0472 mL | 0.2362 mL | 0.4724 mL | 1.1810 mL | |
| 60 mM | 0.0394 mL | 0.1968 mL | 0.3937 mL | 0.9841 mL | |
| 80 mM | 0.0295 mL | 0.1476 mL | 0.2952 mL | 0.7381 mL | |
| 100 mM | 0.0236 mL | 0.1181 mL | 0.2362 mL | 0.5905 mL |
BPH-715 Related Classifications
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