BPIPP
Based on 1 Customer Validation
BPIPP is a guanylyl cyclase type C (GC-C) and adenylyl cyclase inhibitor that can suppress cyclic nucleotide synthesis. BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases, and has the potential for diarrhea research.
For research use only. We do not sell to patients.
- Purity : 98.3%
- CAS No.: 325746-94-9
- Formula: C22H16BrN3O3
- Molecular Weight:450.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T84 | IC50 |
3.4 μM
Compound: 1, BPIPP
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Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 100 nM toxin challenge measured after 10 mins of induction by ELISA
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[PMID: 19409779] |
| T84 | IC50 |
9.6 μM
Compound: 1, BPIPP
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Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
Inhibition of Escherichia coli heat stable toxin A-stimulated cGMP accumulation in human T84 cells pretreated 10 mins before 1 nM toxin challenge measured after 10 mins of induction by ELISA
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[PMID: 19409779] |
In Vitro
BPIPP suppresses stable toxin (STa)-stimulated cGMP accumulation by decreasing GC-C activation in intact T84 human colorectal carcinoma cells. BPIPP inhibits stimulation of guanylyl cyclases, including types A and B and soluble isoform in various cells. BPIPP suppresses stimulation of adenylyl cyclase and significantly decreases the activities of adenylyl cyclase toxin of Bordetella pertussis and edema toxin of Bacillus anthracis. The effects of BPIPP on cyclic nucleotide synthesis were observed only in intact cells[1].
BPIPP inhibits chloride-ion transport stimulated by activation of guanylyl or adenylyl cyclases and suppressed STa-induced fluid accumulation in an in vivo rabbit intestinal loop model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 325746-94-9
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Appearance Solid
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Molecular Weight 450.28
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Formula C22H16BrN3O3
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Color Orange to red
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SMILES
O=C1C2=C(C3=CC=CC=C13)NC(N(C(N(C)C4=O)=O)C)=C4C2C5=CC(Br)=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 1.43 mg/mL (3.18 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2208 mL | 11.1042 mL | 22.2084 mL | 55.5210 mL |
BPIPP Related Classifications
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