CTAP
Based on 2 publication(s) in Google Scholar
CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.
For research use only. We do not sell to patients.
- Purity : 99.30%
- CAS No.: 103429-32-9
- Formula: C51H69N13O11S2
- Molecular Weight:1104.30
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CTAP
MoreAll Opioid Receptor Isoforms
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Biological Activity
Description
IC50 & Target
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μ Opioid Receptor/MOR 3.5 nM (IC50) |
δ Opioid Receptor/DOR 4500 nM (IC50) |
In Vivo
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP is stable in the blood and serum of rats (T1/2 > 500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[1]
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Dosage:0, 0.1, 0.5, 1 mg/kg
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Administration:IP, single
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Result:Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.
Chemical Information
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CAS No. 103429-32-9
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Appearance Solid
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Molecular Weight 1104.30
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Formula C51H69N13O11S2
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Color White to off-white
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Sequence
{d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)
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Sequence Shortening
{d-Phe}-CY-{d-Trp}-RT-{Pen}-T-NH2 (Disulfide bridge:Cys2-Pen7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Epigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model. [Abstract]2023 Nov 9;14(1):7234. PMID: 37945654 -
Pharmacol Biochem Behav
Dual activation of 5-HT1A and μ-opioid receptors mediates dezocine's antidepressant effects in mice with comorbid pain and depression. [Abstract]2026 Feb:259:174136. PMID: 41365431
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (90.56 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1.67 mg/mL (1.51 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Mitchell J Bartlett, et al. Highly-selective µ-opioid Receptor Antagonism Does Not Block L-DOPA-induced Dyskinesia in a Rodent Model.BMC Res Notes [Content Brief]
[2]. Abbruscato TJ, et al. Blood-brain barrier permeability and bioavailability of a highly potent and mu-selective opioid receptor antagonist, CTAP: comparison with morphine. J Pharmacol Exp Ther. 1997 Jan;280(1):402-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.9056 mL | 4.5278 mL | 9.0555 mL | 22.6388 mL |
| DMSO | 5 mM | 0.1811 mL | 0.9056 mL | 1.8111 mL | 4.5278 mL |
| 10 mM | 0.0906 mL | 0.4528 mL | 0.9056 mL | 2.2639 mL | |
| 15 mM | 0.0604 mL | 0.3019 mL | 0.6037 mL | 1.5093 mL | |
| 20 mM | 0.0453 mL | 0.2264 mL | 0.4528 mL | 1.1319 mL | |
| 25 mM | 0.0362 mL | 0.1811 mL | 0.3622 mL | 0.9056 mL | |
| 30 mM | 0.0302 mL | 0.1509 mL | 0.3019 mL | 0.7546 mL | |
| 40 mM | 0.0226 mL | 0.1132 mL | 0.2264 mL | 0.5660 mL | |
| 50 mM | 0.0181 mL | 0.0906 mL | 0.1811 mL | 0.4528 mL | |
| 60 mM | 0.0151 mL | 0.0755 mL | 0.1509 mL | 0.3773 mL | |
| 80 mM | 0.0113 mL | 0.0566 mL | 0.1132 mL | 0.2830 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CTAP Related Classifications
HY-P1335 Related Classifications
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