CYY292
Based on 1 Customer Validation
CYY292 is an FGFR1 inhibitor that specifically targets the FGFR1/AKT/Snail pathway in GBM cells. CYY292 dose-dependently inhibits cancer cell proliferation, epithelial-mesenchymal transition, stemness, invasion, and migration in vitro.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 2644673-04-9
- Formula: C24H28N8O
- Molecular Weight:444.53
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
FGFR1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HOS-TE85 | IC50 |
1.36 μM
Compound: 7l
|
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MNNG/HOS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 35239349] |
| MG-63 | IC50 |
0.84 μM
Compound: 7l
|
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MG-63 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 35239349] |
| SAOS-2 | IC50 |
0.72 μM
Compound: 7l
|
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SAOS-2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 35239349] |
| U2OS | IC50 |
0.76 μM
Compound: 7l
|
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human U2OS cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 35239349] |
Chemical Information
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CAS No. 2644673-04-9
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Appearance Solid
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Molecular Weight 444.53
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Formula C24H28N8O
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Color White to off-white
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SMILES
CN1CCN(C2=C(OC)C=C(NC3=NC(NC4=CC(NN=C5)=C5C=C4)=C(C)C=N3)C=C2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (265 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)