Cat. No.: HY-N0126

Xanthone

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Xanthone is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.84 µM. Xanthon inhibits Norepinephrine (HY-13715) and high-K⁺-induced vasoconstriction with IC₅₀ values of 60.26 μM and 82.9 μM, respectively. Xanthon increases intracellular cyclic adenosine 3′,5′-monophosphate (cAMP) content and blocks Ca²⁺ channels. Xanthone is the scaffold of several pharmacologically active compounds.

For research use only. We do not sell to patients.

Purity: 99.97%
CAS No.: 90-47-1
Formula: C₁₃H₈O₂
Molecular Weight:196.21

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Xanthone Chemical Structure

CAS No.: 90-47-1

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Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

MAO-A

0.84 μM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

All Calcium Channel Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	21.15 μM Compound: Xanthone	Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based analysis Antiinflammatory activity in LPS-induced mouse BV-2 cells assessed as inhibition of NO production incubated for 24 hrs by Griess reagent based analysis	[PMID: 39088998]
DU-145	IC₅₀	>500 μM Compound: 3	Cytotoxicity against human DU145 cells after 48 hrs Cytotoxicity against human DU145 cells after 48 hrs	[PMID: 20129790]
HeLa	IC₅₀	>500 μM Compound: 3	Cytotoxicity against human HeLa cells after 48 hrs Cytotoxicity against human HeLa cells after 48 hrs	[PMID: 20129790]
MCF7	IC₅₀	>500 μM Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs Cytotoxicity against human MCF7 cells after 48 hrs	[PMID: 20129790]

In Vitro

Xanthone relaxes the Norepinephrine (HY-13715)-induced contraction of rat thoracic aorta. The Norepinephrine and high-K⁺-induced vasoconstriction is inhibited dose dependently in aorta pretreated with Xanthone with IC₅₀ values of 60.26 μM and 82.9 μM, respectively^[1].
Xanthone concentration dependently inhibits the Ca²⁺ influx induced by either norepinephrine or high-K⁺, suggesting that Xanthone might act as a blocker of both receptor-operated and voltage-dependent Ca²⁺ channels^[1].
Xanthone causes an increase in the level of intracellular cyclic adenosine 3′,5′-monophosphate (cAMP), but not cyclic guanosine 3′,5′-monophosphate (cGMP) content^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 90-47-1
Appearance Solid
Molecular Weight 196.21
Formula C₁₃H₈O₂
Color White to off-white
SMILES

O=C1C2=C(OC3=C1C=CC=C3)C=CC=C2
Structure Classification
- Phenols
- Xanthones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

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Cell Metab

Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry. [Abstract]

2022 Mar 1;34(3):424-440.e7. PMID: 35150639
Platelets

Xanthone impairs platelet activation and thrombus formation. [Abstract]

2025 Dec;36(1):2597777. PMID: 41399133
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (50.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0966 mL

25.4829 mL

50.9658 mL

5 mM

1.0193 mL

5.0966 mL

10.1932 mL

10 mM

0.5097 mL

2.5483 mL

5.0966 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1 mg/mL (5.10 mM); Clear solution

This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (459 KB)
- English - EN (459 KB)
- Français - FR (459 KB)
- Deutsch - DE (459 KB)
- Norwegian - NO (459 KB)
- Español - ES (459 KB)
- Swedish - SV (459 KB)
- Italian - IT (459 KB)
- Korean - KR (459 KB)
- Portuguese - PT (459 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheng YW, et al. Mechanism of vasorelaxation of thoracic aorta caused by xanthone. Eur J Pharmacol. 1997 Oct 1;336(1):23-8. [Content Brief]

[2]. El-Seedi HR, et al. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem. 2010;17(9):854-901. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	5.0966 mL	25.4829 mL	50.9658 mL	127.4145 mL
	5 mM	1.0193 mL	5.0966 mL	10.1932 mL	25.4829 mL
	10 mM	0.5097 mL	2.5483 mL	5.0966 mL	12.7415 mL
	15 mM	0.3398 mL	1.6989 mL	3.3977 mL	8.4943 mL
	20 mM	0.2548 mL	1.2741 mL	2.5483 mL	6.3707 mL
	25 mM	0.2039 mL	1.0193 mL	2.0386 mL	5.0966 mL
	30 mM	0.1699 mL	0.8494 mL	1.6989 mL	4.2472 mL
	40 mM	0.1274 mL	0.6371 mL	1.2741 mL	3.1854 mL
	50 mM	0.1019 mL	0.5097 mL	1.0193 mL	2.5483 mL

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Xanthone

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Publications Citing Use of MedChemExpress (MCE) Xanthone

All Monoamine Oxidase Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Xanthone Related Classifications

HY-N0126 Related Classifications