2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. NS-8

NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence.

For research use only. We do not sell to patients.

NS-8 Chemical Structure

NS-8 Chemical Structure

CAS No. : 186033-14-7

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Description

NS-8, a pyrrole derivative, activates the Ca2+-sensitive k+-channel. NS-8 can suppress the micturition reflex by decreasing afferent pelvic nerve activity. NS-8 can be used in the research of urinary frequency and incontinence[1].

In Vivo

NS-8 (intravenous injection or intraduodenal administration, 3 and 10 mg/kg) suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 1, 3 and 10 mg/kg
Administration: Intraduodenal administration, intravenous injection
Result: Intraduodenal administration: increased the bladder capacity without affecting the MBCP (bladder contraction pressure).
Intravenous injection: inhibited the IVBCs (isovolumetric bladder contractions) in a dose-dependent manner without affecting the amplitude.
Suppressed the increase in the pelvic afferent discharge frequency and inhibited the increase in intravesical pressure.
Molecular Weight

215.23

Formula

C12H10FN3
CAS No.
SMILES

CC1=C(C2=C(F)C=CC=C2)NC(N)=C1C#N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Keywords:

NS-8186033-14-7NS8NS 8Potassium ChannelKcsAMicturitionbladder capacityoveractive bladderUUIK+ ChannelInhibitorinhibitorinhibit

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