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Cat. No.: HY-116799

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NSC 145669

NSC 145669 is an inhibitor for tubulin polymerization with IC₅₀ of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice.

For research use only. We do not sell to patients.

CAS No.: 31785-60-1
Formula: C₁₈H₁₄N₂O
Molecular Weight:274.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NSC 145669 Chemical Structure

CAS No.: 31785-60-1

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NSC 145669 is an inhibitor for tubulin polymerization with IC₅₀ of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	0.031 μM Compound: 39	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
A-431	GI₅₀	0.02 μM Compound: 39	Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
BE(2)-C	GI₅₀	0.027 μM Compound: 39	Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
DU-145	GI₅₀	0.089 μM Compound: 39	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
HT-29	GI₅₀	0.02 μM Compound: 39	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF-10A	GI₅₀	0.04 μM Compound: 39	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF7	GI₅₀	0.075 μM Compound: 39	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MIA PaCa-2	GI₅₀	0.048 μM Compound: 39	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
NCI-H460	GI₅₀	0.037 μM Compound: 39	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
U-87MG ATCC	GI₅₀	0.22 μM Compound: 39	Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]

Chemical Information

CAS No. 31785-60-1
Molecular Weight 274.32
Formula C₁₈H₁₄N₂O
SMILES

O=C1NC(NC2=C1C=CC=C2)C3=C4C=CC=CC4=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hamel E, et al., Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. Biochem Pharmacol. 1996 Jan 12;51(1):53-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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