nSMase2-IN-1
nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC50 value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research.
For research use only. We do not sell to patients.
- CAS No.: 2968322-24-7
- Formula: C12H17N5O
- Molecular Weight:247.30
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
nSMase2-IN-1 (Compound 11j) (5μM, 60 min) shows excellent metabolic stability in rat liver microsomes with >95% remaining after 1 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (Pharmacokinetic assay)[1]
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Dosage:10 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Absorbed quickly resulting in plasma concentration of more than 2 μM and had higher brain levels than plasma at 0.5 h.
Chemical Information
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CAS No. 2968322-24-7
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Appearance Solid
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Molecular Weight 247.30
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Formula C12H17N5O
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Color Light yellow to yellow
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SMILES
CN(C1=C2N(C=CC(N3CCOCC3)=N2)N=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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