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TXK - TXK tyrosine kinase Gene

Also Known as RLK; TKL; BTKL; PTK4; PSCTK5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7294

About TXK

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:48,066,393-48,134,250 (from NCBI)

This gene has 6 transcripts (splice variants), 117 orthologues and 32 paralogues. Broad expression in lymph node (RPKM 5.7), spleen (RPKM 3.3) and 15 other tissues.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TXK Products (1)

mRNA	Protein	Name
NM_003328.3	NP_003319.2	tyrosine-protein kinase TXK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17177976	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11859127	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	10523612	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	11859127	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12081135	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17177976	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	11859127	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10523612	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10523612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
527 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase TXK	PTK4 protein tyrosine kinase 4

TXK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Validated Y2H	32296183
Intra	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Y2H Array	32296183
Intra	TXK	P42681	ZNF792	Homo sapiens	Q3KQV3	Y2H Prey Pooling	32296183
Intra	TXK	P42681	DOK2	Homo sapiens	O60496	Y2H Prey Pooling	32296183
Intra	TXK	P42681	DOK2	Homo sapiens	O60496	Y2H Array	32296183
Intra	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	TXK	P42681	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	TXK	P42681	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Validated Y2H	32296183
Intra	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Y2H Array	32296183
Intra	TXK	P42681	RBAK	Homo sapiens	Q9NYW8	Y2H Prey Pooling	32296183
Intra	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32296183
Intra	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Y2H Prey Pooling	32296183
Intra	TXK	P42681	GRB10	Homo sapiens	Q13322-4	Y2H Array	32296183
Intra	TXK	P42681	KIT	Homo sapiens	P10721	FPS	24728074
Intra	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Y2H Array	32296183
Intra	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
Intra	TXK	P42681	STAP2	Homo sapiens	Q9UGK3	Y2H Prey Pooling	32296183
Intra	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Validated Y2H	32296183
Intra	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Y2H Array	32296183
Intra	TXK	P42681	IKZF4	Homo sapiens	Q9H2S9	Y2H Prey Pooling	32296183
Intra	TXK	P42681	JRK	Homo sapiens	O75564-2	Y2H Array	32296183
Intra	TXK	P42681	JRK	Homo sapiens	O75564-2	Y2H Prey Pooling	32296183
Intra	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Validated Y2H	32296183
Intra	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	TXK	P42681	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	TXK	P42681	SOCS6	Homo sapiens	O14544	Y2H Array	32296183
Intra	TXK	P42681	SOCS6	Homo sapiens	O14544	Y2H Prey Pooling	32296183
Intra	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	TXK	P42681	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	TXK	P42681	GRB2	Homo sapiens	P62993	Validated Y2H	32296183
Intra	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Y2H Array	32296183
Intra	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Y2H Prey Pooling	32296183
Intra	TXK	P42681	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	32296183
Intra	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	32296183
Intra	TXK	P42681	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	TXK	P42681	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	TXK	P42681	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	TXK	P42681	SOCS3	Homo sapiens	O14543	Y2H Array	32296183
Intra	TXK	P42681	SOCS3	Homo sapiens	O14543	Y2H Prey Pooling	32296183
Intra	TXK	P42681	DUSP6	Homo sapiens	Q16828	Validated Y2H	32296183
Intra	TXK	P42681	DUSP6	Homo sapiens	Q16828	Y2H Array	32296183
Intra	TXK	P42681	DUSP6	Homo sapiens	Q16828	Y2H Prey Pooling	32296183
Intra	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Validated Y2H	32296183
Intra	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Y2H Array	32296183
Intra	TXK	P42681	TNS4	Homo sapiens	Q8IZW8	Y2H Prey Pooling	32296183
Intra	TXK	P42681	CRK	Homo sapiens	P46108	Y2H Prey Pooling	32296183
Intra	TXK	P42681	CRK	Homo sapiens	P46108	Validated Y2H	32296183
Intra	TXK	P42681	CRK	Homo sapiens	P46108	Y2H Array	32296183
Intra	TXK	P42681	PIK3R1	Homo sapiens	P27986-2	Y2H Prey Pooling	32296183
Intra	TXK	P42681	PIK3R1	Homo sapiens	P27986-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Agammaglobulinemia, X-Linked	X-Linked Agammaglobulinemia XLA Bruton Type Agammaglobulinemia Bruton'S Agammaglobulinemia Bruton-Type Agammaglobulinemia Agmx1 Imd1 Agammaglobulinemia, X-Linked 1 Btk-Deficiency Agammaglobulinemia Hypogammaglobulinemia Agammaglobulinemia, X-Linked, Type 1 Immunodeficiency 1 Bruton Agammaglobulinemia Tyrosine Kinase Deficiency Bruton Disease Bruton'S Agammaglobulinaemia Bruton'S Sex-Linked Agammaglobulinemia Bruton'S Type Agammaglobulinemia Btk Deficiency Agammaglobulinemia, Btk Agammaglobulinemia, Bruton Tyrosine Kinase Congenital Agammaglobulinemia Immunodeficiency Type 1 X-Linked Agammaglobulinemia Type 1
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10644	Lck inhibitor 2	Inhibitor	99.73%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TXK	VGNC	VGNC:48005
Bos taurus	TXK	VGNC	VGNC:36529
Mus musculus	TXK	MGD	MGI:102960
Felis catus	TXK	VGNC	VGNC:66719
Macaca mulatta	TXK	VGNC	VGNC:78678
Rattus norvegicus	TXK	RGD	RGD:1306481
Others	TXK	NCBI