DETA NONOate
Based on 10 publication(s) in Google Scholar
DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 146724-94-9
- Formula: C4H13N5O2
- Molecular Weight:163.18
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Storage:
-80°C
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DETA NONOate
More- Nature. 2025 Sep;645(8079):244-253. [Abstract]
- Cancer Cell. 2024 Jun 10;42(6):1032-1050.e10. [Abstract]
- Adv Sci (Weinh). 2024 May 17:e2401269. [Abstract]
- Int J Biol Macromol. 2024 Apr 4;267(Pt 1):131409. [Abstract]
- J Med Chem. 2025 Sep 25;68(18):19781-19790. [Abstract]
- Virulence. 2026 Dec;17(1):2654293. [Abstract]
- Eur J Pharmacol. 2025 Nov 5:1006:178190. [Abstract]
- Acad Radiol. 2025 Jul;32(7):4121-4133. [Abstract]
- J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
- bioRxiv. 2026 Apr 1:2026.03.31.715625. [Abstract]
Customer Validation & Images
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Cell Migration/Invasion Assay
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Bio/Physico-chemical Assay
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RT-PCR
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RT-PCR
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IP
Biological Activity
DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (Sixty-two, male, 200-250 g)[2]
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Dosage:15 or 150 μg per rat
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Administration:i.c.v., once
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Result:Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue (HY-14536).
Chemical Information
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CAS No. 146724-94-9
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Appearance Solid
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Molecular Weight 163.18
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Formula C4H13N5O2
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Color White to off-white
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SMILES
O=NN(O)N(CCN)CCN
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Synonyms
Diethylamine NONOate; NOC-18
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Shipping
Shipping with dry ice.
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Storage
-80°C
Publications (10)
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Journal Impact Factor
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Most Recent
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Nature
2025 Sep;645(8079):244-253. PMID: 40562926
DETA NONOate purchased from MedChemExpress. Usage Cited in: Nature. 2025 Sep;645(8079):244-253. [Abstract]
NO donor DETA NONOate (100 μM) restored NO activity and substantially improved motility of BMDC.
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Cancer Cell
Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy. [Abstract]2024 Jun 10;42(6):1032-1050.e10. PMID: 38759656 -
Adv Sci (Weinh)
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity. [Abstract]2024 May 17:e2401269. PMID: 38757665
DETA NONOate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 May 17:e2401269. [Abstract]
mRNA levels of CAF markers, pro-tumor factors, and immune-modulatory factors were analyzed by qPCR in the CAFs with hydrogen treatment followed by DETA NONOate (DETA/NO) (100–500 μM) treatment.
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Int J Biol Macromol
Chitosan-based hybrid nanospheres for vessel normalization towards enhancing tumor chemotherapy. [Abstract]2024 Apr 4;267(Pt 1):131409. PMID: 38582478 -
J Med Chem
Discovery of a Novel COS/H2S-Donor Hybridized sGC Stimulator for Alleviating Isoproterenol-Induced Myocardial Fibrosis. [Abstract]2025 Sep 25;68(18):19781-19790. PMID: 40934896 -
Virulence
Phosphorylation of a novel STK substrate SstP1 links SUF Fe-S cluster biogenesis to oxidative stress resistance and virulence in Streptococcus suis. [Abstract]2026 Dec;17(1):2654293. PMID: 41984734 -
Eur J Pharmacol
HEC95468, a novel soluble guanylate cyclase stimulator, shows protection in the Dahl model of cardiorenal disorder. [Abstract]2025 Nov 5:1006:178190. PMID: 40998191
DETA NONOate purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2025 Nov 5:1006:178190. [Abstract]
The NO donor DETA NONOate (DETA-NO) (100 μM; 30 min) synergistically enhanced the ability of HEC95468 to stimulate cGMP production in CHO-Kl-Rat sGC cells, with an EC50 of 0.133 μM.
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Acad Radiol
Ultrasound-Stimulated Microbubbles Cavitation Combined with Nitric Oxide Signaling Pathway to Alleviate Tumor Hypoperfusion and Hypoxia in MC38 Tumor Model. [Abstract]2025 Jul;32(7):4121-4133. PMID: 40234163 -
J Cell Mol Med
Nitric oxide facilitates the S-nitrosylation and deubiquitination of Notch1 protein to maintain cancer stem cells in human NSCLC. [Abstract]2024 Nov;28(21):e70203. PMID: 39523215
DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
DETA NONOate (20 μM; 24 h) significantly upregulated PROM1, ALDH1, POU5F1 and SOX2 mRNA expressions in non-CSCs.
DETA NONOate purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2024 Nov;28(21):e70203. [Abstract]
DETA NONOate (20 μM) induced S-nitrosylation of Notch1 and elevated binding of Notch1 to UCHL1 in CSCs.
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bioRxiv
2026 Apr 1:2026.03.31.715625. PMID: 41959463
Solvent & Solubility
H2O : 50 mg/mL (306.41 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419. [Content Brief]
[2]. S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5 [Content Brief]
[3]. Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887. [Content Brief]
[4]. Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months. When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 6.1282 mL | 30.6410 mL | 61.2820 mL | 153.2051 mL |
| 5 mM | 1.2256 mL | 6.1282 mL | 12.2564 mL | 30.6410 mL | |
| 10 mM | 0.6128 mL | 3.0641 mL | 6.1282 mL | 15.3205 mL | |
| 15 mM | 0.4085 mL | 2.0427 mL | 4.0855 mL | 10.2137 mL | |
| 20 mM | 0.3064 mL | 1.5321 mL | 3.0641 mL | 7.6603 mL | |
| 25 mM | 0.2451 mL | 1.2256 mL | 2.4513 mL | 6.1282 mL | |
| 30 mM | 0.2043 mL | 1.0214 mL | 2.0427 mL | 5.1068 mL | |
| 40 mM | 0.1532 mL | 0.7660 mL | 1.5321 mL | 3.8301 mL | |
| 50 mM | 0.1226 mL | 0.6128 mL | 1.2256 mL | 3.0641 mL | |
| 60 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5534 mL | |
| 80 mM | 0.0766 mL | 0.3830 mL | 0.7660 mL | 1.9151 mL | |
| 100 mM | 0.0613 mL | 0.3064 mL | 0.6128 mL | 1.5321 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
DETA NONOate Related Classifications
HY-136278 Related Classifications
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