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Cat. No.: HY-125357

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Ternatin

Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC₅₀ of 0.027 μM in 3T3-L1 adipocytes.

For research use only. We do not sell to patients.

CAS No.: 148619-41-4
Formula: C₃₇H₆₇N₇O₈
Molecular Weight:737.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ternatin Chemical Structure

CAS No.: 148619-41-4

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Sample (0.1mg)

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells assessed as liberated triglyceride after 7 days	[PMID: 18798610]
3T3-L1	IC₅₀	0.027 μM Compound: 1	Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days Inhibition of fat accumulation in mouse 3T3L1 cells after 7 days	[PMID: 19022665]
3T3-L1	IC₅₀	0.027 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Inhibition of fat-accumulation in mouse 3T3L1 cells Inhibition of fat-accumulation in mouse 3T3L1 cells	[PMID: 19097891]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Toxicity in mouse 3T3L1 cells Toxicity in mouse 3T3L1 cells	[PMID: 18798610]
3T3-L1	IC₅₀	0.28 μM Compound: 1	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19022665]
3T3-L1	IC₅₀	0.28 μM Compound: 2, cyclo-[D-allo-Ile1-NMe-L-Ala2-NMe-L-Leu3-L-Leu4-NMe-L-Ala5-NMe-D-Ala6-beta-OH-D-Leu7]	Cytotoxicity against mouse 3T3L1 cells Cytotoxicity against mouse 3T3L1 cells	[PMID: 19097891]

Chemical Information

CAS No. 148619-41-4
Molecular Weight 737.97
Formula C₃₇H₆₇N₇O₈
Sequence

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)
Sequence Shortening

Cyclo({Ala(N-Me)}-{d-Ala((N-Me)}-{d-Leu((3R)-3-hydroxy)}-{d-Ile}-{Ala(N-Me)}-Leu-Leu)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kenichiro Shimokawa, et al. Structure-based hybridization of the bioactive natural products rhizonin A and ternatin leading to a selective fat-accumulation inhibitor against 3T3-L1 adipocytes. Bioorg Med Chem Lett. 2009 Feb 1;19(3):867-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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