Cationic Lipids & Ionizable Lipids
The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.
Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.
- Fòrmula: C44H82N2O2
- Peso molecular: 671.13
Lipid 8 is an ionizable amino lipid that can be used to synthesize lipid nanoparticles (LNPs). Lipid 8 is applicable to research in drug delivery.
- Fòrmula: C46H85N3O2
- Peso molecular: 712.19
Lipid 10 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
- Fòrmula: C49H102N6O2
- Peso molecular: 807.37
Transfectam is a cationic lipid able to interact with DNA to form complexes that mediate efficient gene transfer into various eukaryotic cells.
- Fòrmula: C50H95N3O4
- Peso molecular: 802.31
LNP Lipid-3 is an ionizable lipid that can be used to synthesize lipid nanoparticles. LNP Lipid-3 is applicable for mRNA delivery.
- Fòrmula: C60H125N5O5
- Peso molecular: 996.67
C10-200 is an ionizable cationic lipid that can be used to generate lipid nanoparticles (LNPs). C10-200 is used in the study of mRNA delivery.
- Fòrmula: C38H75Cl5N4O2
- Peso molecular: 797.29
GL67 pentahydrochloride (N4-Spermine cholesteryl carbamate pentahydrochloride) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 pentahydrochloride enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 pentahydrochloride mediates the transduction of plasmid DNA into cells. GL67 pentahydrochloride can be used in drug delivery-related research.
- Fòrmula: C11H22ClNO4
- Peso molecular: 267.75
Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum.
- Fòrmula: C41H74O3
- Peso molecular: 615.02
LNP Lipid-7 is a cationic lipid. LNP Lipid-7 can be used to prepare lipid nanoparticles (LNPs) for the delivery of drugs such as nucleic acids.
- Fòrmula: C83H147N3O16S4
- Peso molecular: 1571.33
4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs).
- Fòrmula: C37H73NO4
- Peso molecular: 595.98
16:0 DAP is an ionizable cationic lipid. 1,2-dipalmitoyl-3-dimethylammonium-propane serves as a barcode lipid, enabling LC-MS quantification in ocular tissues.
- Fòrmula: C49H83NO6
- Peso molecular: 782.19
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery.
- Fòrmula: C34H68ClNO4
- Peso molecular: 590.36
DMTAP is a cationic lipid that can be used for delivery of DNA, RNAi and drugs.
- Fòrmula: C71H131N3O16S4
- Peso molecular: 1411.07
4A3-SC7 is a polymer of 4A3 amine and is an ionizable lipid component. 4A3-SC7 can be used to prepare lipid nanoparticles (LNPs) to construct a selective organ targeting (SORT) LNP platform.
- Fòrmula: C43H81NO
- Peso molecular: 628.11
YSK 12C4 is an ionizable cationic lipid primarily used to enhance siRNA cellular delivery via multifunctional envelope-type nanodevices (MEND). YSK 12C4 promotes siRNA uptake and endosomal escape, effectively silencing genes in human immune cell lines.
- Fòrmula: C42H80NO8P
- Peso molecular: 758.06
1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) is a phosphatidylcholine phospholipid. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC and oxidized derivatives serve as models for investigating lipid peroxidation, membrane structure, and phospholipase A2 activity. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC can be applied in research on atherosclerosis, oxidative stress, and the properties of lipid bilayers.
- Fòrmula: C73H147N7O4S8
- Peso molecular: 1443.51
113-N16B is an ionizable cationic lipid that can be used for the synthesis of lipid nanoparticles. 113-N16B delivers mRNA to pulmonary endothelial cells. 113-N16B can be formulated as a component into hybrid lipid nanoparticles for lung-specific delivery of mRNA (including MFSD7C mRNA and luciferase mRNA) in mice. 113-N16B is applicable to research related to lymphangioleiomyomatosis, sickle cell disease, and hemolysis-induced lung injury.
- Fòrmula: C66H138N6O9S
- Peso molecular: 1191.90
ZA3-Ep10 is a zwitterionic lipid used in lipid nanoparticles formulation for in vivo RNA delivery.
