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Cat. No.: HY-187982

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P2000N-09254

P2000N-09254 is a non-selective inverse agonist of the SREB family (GPR27, GPR85, GPR173). P2000N-09254 inhibits basal Gs-mediated GTPγS binding and shows no ligand activity against TGR5, GPR3, or GPR119 Gsα fusion proteins.

For research use only. We do not sell to patients.

CAS No.: 374699-18-0
Formula: C₁₈H₁₈N₂O₄
Molecular Weight:326.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

P2000N-09254 Chemical Structure

CAS No.: 374699-18-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

P2000N-09254 (compound 1a) is an inverse agonist at GPR173-Gsα, GPR85-Gsα, and GPR27-Gsα fusion proteins in [³⁵S]GTPγS-binding assays, with IC₅₀ values of 12, 14, and 10 µM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 374699-18-0
Molecular Weight 326.35
Formula C₁₈H₁₈N₂O₄
SMILES

OC1=CC(O)=C(C2=NNC(C)=C2OC3=CC=C(C=C3)OCC)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yanai T, et al. Identification and molecular docking studies for novel inverse agonists of SREB, super conserved receptor expressed in brain. Genes to cells : devoted to molecular & cellular mechanisms. 2016 Jul;21(7):717-27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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