PA3552-IN-1
Based on 1 Customer Validation
PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression.
For research use only. We do not sell to patients.
- Purity: 98.55%
- CAS No.: 1008121-12-7
- Formula: C13H8ClFN2O4
- Molecular Weight:310.67
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Antibacterial Compound Library
HY-L049
-
Anti-Pulmonary Fibrosis Compound Library
HY-L125
-
Immunopotentiator Compound Library
HY-L172
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
1.52 μM
Compound: 88
|
Inhibition of KIX-RLucN fused CBP (unknown origin) binding to KID-RLucC fused CREB (unknown origin) transfected in human HEK293 cells preincubated with compound 30 mins before before forskolin addition and measured after 90 mins in presence of coelenteraz
Inhibition of KIX-RLucN fused CBP (unknown origin) binding to KID-RLucC fused CREB (unknown origin) transfected in human HEK293 cells preincubated with compound 30 mins before before forskolin addition and measured after 90 mins in presence of coelenteraz
|
[PMID: 31253529] |
| HL-60 | IC50 |
0.28 μM
Compound: 88
|
Cytotoxicity against human HL60 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human HL60 cells incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 31253529] |
| Jurkat | IC50 |
0.53 μM
Compound: 88
|
Cytotoxicity against human Jurkat cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human Jurkat cells incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 31253529] |
| KG-1 | IC50 |
0.49 μM
Compound: 88
|
Cytotoxicity against human KG1 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human KG1 cells incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 31253529] |
| NALM-6 | IC50 |
0.91 μM
Compound: 88
|
Cytotoxicity against human NALM6 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human NALM6 cells incubated for 3 days by CellTiter-Glo luminescent assay
|
[PMID: 31253529] |
| Vero C1008 | CC50 |
8.15 μM
Compound: 22
|
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against African Green monkey Vero E6 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
|
[PMID: 35344901] |
Chemical Information
-
CAS No. 1008121-12-7
-
Appearance Solid
-
Molecular Weight 310.67
-
Formula C13H8ClFN2O4
-
Color White to off-white
-
SMILES
O=C(C1=C(C=CC(F)=C1)O)NC2=CC=C(C=C2Cl)[N+]([O-])=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 13.89 mg/mL (44.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2188 mL | 16.0942 mL | 32.1885 mL | 80.4712 mL |
| 5 mM | 0.6438 mL | 3.2188 mL | 6.4377 mL | 16.0942 mL | |
| 10 mM | 0.3219 mL | 1.6094 mL | 3.2188 mL | 8.0471 mL | |
| 15 mM | 0.2146 mL | 1.0729 mL | 2.1459 mL | 5.3647 mL | |
| 20 mM | 0.1609 mL | 0.8047 mL | 1.6094 mL | 4.0236 mL | |
| 25 mM | 0.1288 mL | 0.6438 mL | 1.2875 mL | 3.2188 mL | |
| 30 mM | 0.1073 mL | 0.5365 mL | 1.0729 mL | 2.6824 mL | |
| 40 mM | 0.0805 mL | 0.4024 mL | 0.8047 mL | 2.0118 mL |
PA3552-IN-1 Related Classifications
HY-144767 Related Classifications
Powered by Bioz