country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P1180B

Copy Link Print Information

Pam3CSK4 trihydrochloride

(Synonyms: Pam3Cys-Ser-(Lys)4 trihydrochloride)

22 Cited Publications

Avis client

Based on 22 publication(s) in Google Scholar

Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 112208-04-5
Formule: C₈₁H₁₅₉Cl₃N₁₀O₁₃S
Masse moléculaire:1619.61

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pam3CSK4 trihydrochloride Chemical Structure

CAS No.: 112208-04-5

Size

Prix

Stock

Quantité

Amount: USD 0.00

or

or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (22)
Pureté et documentation
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Pam3Cys-Ser-(Lys)4 trihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

IC₅₀ & Target

TLR1

TLR2

Chemical Information

CAS No. 112208-04-5
Masse moléculaire 1619.61
Formule C₈₁H₁₅₉Cl₃N₁₀O₁₃S
Synonyms

Pam3Cys-Ser-(Lys)4 trihydrochloride
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (22)

All WBELISA

Sort by:

Journal Impact Factor

Nat Immunol

Delaying pyroptosis with an AI-screened gasdermin D pore blocker mitigates inflammatory response. [Abstract]

2025 Oct;26(10):1660-1672. PMID: 40954252

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

Pam3CSK4 (Pam3; 1 µg/mL; 12 h). ELISA of secreted from wild-type BMDCs treated with PBS, BFP, GSDMD-NT, SK56, SK56 + GSDMD-NT, oxPAPC, SK56 + oxPAPC or pyroptotic cytomembrane fragments from mouse wild-type or Gsdmd−/− BMDMs as in c (NCF, PCF, PCF + SK56, PCF^Gsdmd−/−, PCF^Gsdmd−/− + SK56), treated or not treated with Pam3 for 12 h.
J Adv Res

4-Octyl itaconate-induced Nrf2 nuclear translocation mitigates Caspase-11-dependent noncanonical macrophage pyroptosis and acute lung injury. [Abstract]

2026 May 4:S2090-1232(26)00378-4. PMID: 42092588
Mol Biomed

Death-associated protein kinase 2 (DAPK2) propagates endoplasmic reticulum stress in macrophages to worsen sepsis through HSPA5-IRE1α axis. [Abstract]

2026 Jun 23;7(1):94. PMID: 42334722
J Control Release

Development of a lymph node-homing peptide vaccine targeting C-C chemokine receptor 7-positive dendritic cells with enhanced antitumor immunity. [Abstract]

2026 Mar 10:391:114645. PMID: 41580130
Phytomedicine

Gusongan capsule enhances osteogenic differentiation to mitigate bone loss in ovariectomized rats via the TLR2/NF-κB pathway. [Abstract]

2025 Jun:141:156705. PMID: 40215821
J Pharm Anal

Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway. [Abstract]

2025 Jan;15(1):101054. PMID: 39906691

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Jan;15(1):101054. [Abstract]

Representative immunoblot images after the treatment of Oxymatrine (40 μM), Pam3CSK4 (3 μM), for five days.
Chin Herb Med

Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair. [Abstract]

2024 Apr 30;16(3):422-434. PMID: 39072201

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Chin Herb Med. 2024 Apr 30;16(3):422-434. [Abstract]

Pam3CSK4 (400 ng/mL; 4 h). Relative protein expression levels of Casp-1 p20 in BMDMs.

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Chin Herb Med. 2024 Apr 30;16(3):422-434. [Abstract]

Pam3CSK4 (400 ng/mL; 4 h). LPS-primed BMDMs with LJF, FF, or vehicle for 1 h and then stimulated with Pam3CSK4-primed BMDMs were pretreated with LJF, FF, or vehicle and then stimulated with transfected LPS. Activated caspase-1 (P20) and cleaved IL-1β (P17) in culture supernatants (SN) of BMDMs and NLRP3, ASC, pro-caspase-1(p45), pro-IL-1β in whole-cell lysates (WCL) by western blot analyses.
NPJ Sci Food

Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling. [Abstract]

2026 Jan 23;10(1):73. PMID: 41577727
Sci China Life Sci

Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases. [Abstract]

2024 Dec;67(12):2664-2677. PMID: 39190126
Food Res Int

2026 Feb 6.
Atherosclerosis

Isolinderalactone alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages. [Abstract]

2026 Jan 26:414:120648. PMID: 41759391
Int Immunopharmacol

Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathways. [Abstract]

2022 Dec;113(Pt A):109312. PMID: 36252491
Int Immunopharmacol

SIX1 attenuates inflammation and rheumatoid arthritis by silencing MyD88-dependent TLR1/2 signaling. [Abstract]

2022 May:106:108613. PMID: 35180623
PLoS Pathog

Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia. [Abstract]

2024 Nov 5;20(11):e1012614. PMID: 39499730

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2024 Nov 5;20(11):e1012614. [Abstract]

Pam3CSK4 (1 µg/mL; 12 h). Irg1 mRNA expression in neutrophils, pooled from three independent experiments.
Sci Rep

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer. [Abstract]

2023 Nov 9;13(1):19440. PMID: 37945630
Sci Rep

A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics. [Abstract]

2022 Oct 12;12(1):17058. PMID: 36224298
Antiviral Res

TLR2-mediated mucosal immune priming boosts anti-rhabdoviral immunity in early vertebrates. [Abstract]

2022 Jul:203:105346. PMID: 35605698
Naunyn Schmiedebergs Arch Pharmacol

Quercetin inhibits microglial pyroptosis following intracerebral hemorrhage via the TLR2/MyD88/NF-κB signaling pathway. [Abstract]

2026 Jan 19. PMID: 41549176
J Funct Foods

2026 May 30;142:107364.
Mol Immunol

Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin. [Abstract]

2021 Feb:130:85-95. PMID: 33250268
Microbes Infect

Corydalis Saxicola Bunting Total Alkaloid Eliminates Porphyromonas gingivalis strain 33277 Internalized into Macrophages by Inhibition of TLR2. [Abstract]

2024 Jan-Feb;26(1-2):105244. PMID: 37914020
Biochem Biophys Res Commun

Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production. [Abstract]

2024 Apr 16:704:149661. PMID: 38417343

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (232 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=

Concentration Concentration

×

Volume Volume

×

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

×

Volume _(start) Volume _(start)

=

Concentration _(final) Concentration _(final)

×

Volume _(final) Volume _(final)

Bioz

Keywords

Pam3CSK4 trihydrochloride

22 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

Subscribe

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Publications (22)
Pureté et documentation

1/16
1/16

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

Customer Validation
Pam3CSK4 (Pam3; 1 µg/mL; 12 h). ELISA of secreted from wild-type BMDCs treated with PBS, BFP, GSDMD-NT, SK56, SK56 + GSDMD-NT, oxPAPC, SK56 + oxPAPC or pyroptotic cytomembrane fragments from mouse wild-type or Gsdmd−/− BMDMs as in c (NCF, PCF, PCF + SK56, PCF^Gsdmd−/−, PCF^Gsdmd−/− + SK56), treated or not treated with Pam3 for 12 h.
1/16

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2025 Jan;15(1):101054. [Abstract]

Customer Validation
Representative immunoblot images after the treatment of Oxymatrine (40 μM), Pam3CSK4 (3 μM), for five days.
1/16

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Chin Herb Med. 2024 Apr 30;16(3):422-434. [Abstract]

Customer Validation
Pam3CSK4 (400 ng/mL; 4 h). Relative protein expression levels of Casp-1 p20 in BMDMs.
1/16

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: Chin Herb Med. 2024 Apr 30;16(3):422-434. [Abstract]

Customer Validation
Pam3CSK4 (400 ng/mL; 4 h). LPS-primed BMDMs with LJF, FF, or vehicle for 1 h and then stimulated with Pam3CSK4-primed BMDMs were pretreated with LJF, FF, or vehicle and then stimulated with transfected LPS. Activated caspase-1 (P20) and cleaved IL-1β (P17) in culture supernatants (SN) of BMDMs and NLRP3, ASC, pro-caspase-1(p45), pro-IL-1β in whole-cell lysates (WCL) by western blot analyses.
1/16

Pam3CSK4 trihydrochloride purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2024 Nov 5;20(11):e1012614. [Abstract]

Customer Validation
Pam3CSK4 (1 µg/mL; 12 h). Irg1 mRNA expression in neutrophils, pooled from three independent experiments.