2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. PARP-1-IN-4

PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma.

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PARP-1-IN-4

PARP-1-IN-4 Estructura química

No. CAS : 684234-56-8

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PARP-1-IN-4 Related Antibodies

Top Publications Citing Use of Products

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Descripciòn

PARP-1-IN-4 is a PARP-1 inhibitor. PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM. PARP-1-IN-4 can be used for the research of lung adenocarcinoma[1].

IC50 & Target

IC50: 302 μM (PARP-1)[1]
In Vitro

PARP-1-IN-4 has inhibitory activity against PARP-1 with IC50 value of 302 μM[1].
PARP-1-IN-4 (0.1, 1 and 10 μM; 24h and 48h) has cytotoxicity activity against A549 cells[1].
PARP-1-IN-4 (1 μM; 24h) exhibits a significant increase in the expression levels of caspase-3 and caspase-9protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP-1-IN-4 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A549 cells
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24h and 48h
Result: Exhibited cytotoxicity activity against A549 cells.
Peso molecular

424.28

Fòrmula

C22H15Cl2N3O2
No. CAS
Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(CN1N=C(C2=C(C1=O)C=CC=C2)C3=CC=C(Cl)C=C3)NC4=CC=C(C=C4)Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 7.69 mg/mL (18.12 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3569 mL 11.7847 mL 23.5693 mL
5 mM 0.4714 mL 2.3569 mL 4.7139 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3569 mL 11.7847 mL 23.5693 mL 58.9234 mL
5 mM 0.4714 mL 2.3569 mL 4.7139 mL 11.7847 mL
10 mM 0.2357 mL 1.1785 mL 2.3569 mL 5.8923 mL
15 mM 0.1571 mL 0.7856 mL 1.5713 mL 3.9282 mL
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PARP-1-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-1-IN-4684234-56-8PARPpoly ADP ribose polymerasePARP-1lung adenocarcinomaphthalazinonesInhibitorinhibitorinhibit

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Nombre del producto:
PARP-1-IN-4
Cat. No.:
HY-153590
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