country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-W787896

Copy Link Print Information

PDE4-IN-25

Name: PDE4-IN-25
Brand: MedChemExpress
SKU: HY-W787896
Price: 105.00 USD
Availability: InStock
Rating: 5 (1 reviews)

PDE4-IN-25 (compound 12) is a potent inhibitor of PDE4，with the IC₅₀ of 0.1 μM. PDE4-IN-25 plays an important role in inflammatory diseases research.

For research use only. We do not sell to patients.

CAS No.: 346440-86-6
Formula: C₁₄H₁₅N₃O₄
Molecular Weight:289.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PDE4-IN-25 Chemical Structure

CAS No.: 346440-86-6

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PDE4-IN-25 (compound 12) is a potent inhibitor of PDE4，with the IC₅₀ of 0.1 μM. PDE4-IN-25 plays an important role in inflammatory diseases research^[1].

IC₅₀ & Target

PDE4

0.1 μM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 346440-86-6
Molecular Weight 289.29
Formula C₁₄H₁₅N₃O₄
SMILES

O=C(C1=C(C)N(C2=CC([N+]([O-])=O)=CC=C2)N=C1C)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Icos Corp. Preparation of pyrazoles as cAMP-specific phosphodiesterase inhibitors for pharmaceutical use as anti-inflammatory agents. World Intellectual Property Organization, WO2001046172 A1 2001-06-28.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PDE4-IN-25

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

PDE4-IN-25 Related Classifications

HY-W787896 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target