1. PROTAC
  2. PROTAC Linker
  3. PEG5-Tos

PEG5-Tos 

Cat. No.: HY-23417
Handling Instructions

PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

PEG5-Tos Chemical Structure

PEG5-Tos Chemical Structure

CAS No. : 155130-15-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 280 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Molecular Weight

392.46

Formula

C₁₇H₂₈O₈S

CAS No.

155130-15-7

SMILES

CC1=CC=C(S(OCCOCCOCCOCCOCCO)(=O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5480 mL 12.7402 mL 25.4803 mL
5 mM 0.5096 mL 2.5480 mL 5.0961 mL
10 mM 0.2548 mL 1.2740 mL 2.5480 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PEG5-TosPROTAC LinkerInhibitorinhibitorinhibit

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Product name:
PEG5-Tos
Cat. No.:
HY-23417
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