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Art. -Nr.: HY-142656

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PIM-IN-1

Name: PIM-IN-1
Brand: MedChemExpress
SKU: HY-142656
Availability: PreOrder

PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC₅₀ = 61 nM; pS6, EC₅₀ = 71 nM).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₅H₁₈ClFN₄O

Molecular Weight:324.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PIM-IN-1 Chemical Structure

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This product is a controlled substance, please contact local distributor for purchase. This product is a controlled substance and not for sale in your territory.

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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

Data Download

Data Sheet (271 KB)

Handling Instructions (2659 KB)

To place orders, for customer services and technical support, please contact:

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Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Help & FAQs

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Alle Pim Isoform-spezifische Produkte anzeigen
More

PIM1

PIM2

PIM3

Biologische Aktivität

Beschreibung

Cellular Effect

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Classifications

Bioz

Biologische Aktivität

Beschreibung

PIM-IN-1 is a pan-PIM kinase inhibitor (KG-1, EC₅₀ = 61 nM; pS6, EC₅₀ = 71 nM).

Alle Pim Isoform-spezifische Produkte anzeigen :

PIM1

PIM2

PIM3

Cellular Effect

Cell Line

Type Value Description References

KG-1 EC₅₀
61 nM
Compound: 27

Cytotoxicity against human KG-1 cells assessed as reduction in cell viability

Cytotoxicity against human KG-1 cells assessed as reduction in cell viability
[PMID: 33096160]

KG-1 EC₅₀
7230 nM
Compound: 25

Cytotoxicity against human KG-1 cells assessed as reduction in cell viability

Cytotoxicity against human KG-1 cells assessed as reduction in cell viability
[PMID: 33096160]

Chemical Information

Molecular Weight 324.78

Formel C₁₅H₁₈ClFN₄O

SMILES

O=C(C1=CC(Cl)=C2C(N([C@H]([C@@]3(F)CNCC3)C)C=C2C)=N1)N

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Barberis C, et al. Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127625. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

=
Konzentration Konzentration

×
Volumen Volumen

×
Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

×

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

=

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

×

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

PIM-IN-1 Related Classifications

HY-142656 Related Classifications

JAK/STAT Signaling

Pim

Disease Areas

Cancer

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Bioz

Powered by Bioz See more details on Bioz

Keywords

PIM-IN-1
Pim
Pim kinases
Inhibitor
inhibitor
inhibit

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