1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Pipecuronium bromide

Pipecuronium bromide 

Cat. No.: HY-B0743A
Handling Instructions

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM.

For research use only. We do not sell to patients.

Pipecuronium bromide Chemical Structure

Pipecuronium bromide Chemical Structure

CAS No. : 52212-02-9

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Description

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM[1][2][3][4][5].

IC50 & Target

nAChR[4][5]

In Vitro

Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium[1].

In Vivo

The average ED95 is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED95, and anaphylaxis does not appear to be a problem[2].
Carboxymethylated γ-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment[3].

Molecular Weight

762.70

Formula

C₃₅H₆₂Br₂N₄O₄

CAS No.

52212-02-9

SMILES

C[[email protected]@]1([[email protected]]2OC(C)=O)[[email protected]](C[[email protected]@H]2N3CC[N+](C)(C)CC3)([H])[[email protected]@](CC[[email protected]]4([H])[[email protected]@]5(C[[email protected]](N6CC[N+](C)(C)CC6)[[email protected]@H](OC(C)=O)C4)C)([H])[[email protected]]5([H])CC1.[Br-].[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PipecuroniumnAChRNicotinic acetylcholine receptorsLong-actingsteroidalneuromuscularblockingagentsafetynondepolarizingInhibitorinhibitorinhibit

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Pipecuronium bromide
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HY-B0743A
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