PKG1α activator 3
PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM). PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2773367-58-9
- 分子式: C27H26Cl2N2O6
- 分子量:545.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PKG1α activator 3 (11.7-33.3 μM; 45 min) shows phosphorylation of VASP[1].
PKG1α activator 3 (6.2-22.8 μM; 24 h) inhibits PDGF-induced cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Smooth muscle cells
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Concentration:6.2-22.8 μM
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Incubation Time:24 hours
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Result:Inhibited hPASMC proliferation EC50 value of 6 μM.
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Cell Line:HEK 293 cells
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Concentration:11.7-33.3 μM
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Incubation Time:45 min
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Result:Showed pVASP cell EC50 value of 13.4 μM.
| pharmacokinetic parameters | ||||
| Compound | Cl (mL/min/kg) | Vd (L/kg) | MRT (h) | PPB (%) |
| PKG1α activator 3 | 8.1 | 0.45 | 0.9 | >99.9 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2773367-58-9
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分子量 545.41
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分子式 C27H26Cl2N2O6
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SMILES
O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PKG1α activator 3 関連分類
HY-151203 関連分類
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