1. Natural Products
  2. Disease Research Fields Plants Terpenoids
  3. Campanulaceae Inflammation/Immunology Metabolic Disease Triterpenes
  4. Platycodon grandiflorus (Jacq.) A. DC.
  5. Platyconic acid A

Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation.

For research use only. We do not sell to patients.

Platyconic acid A Chemical Structure

Platyconic acid A Chemical Structure

CAS No. : 68051-23-0

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5 mg USD 400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation[1].

In Vitro

Platyconic Acid A (0.5~2 μM; 30 minutes; A549 cells) inhibits PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner[1].
Platyconic Acid A (0.5~2 μM; 24 hours; A549 cells) decreases PMA-increased MUC5AC mRNA expression in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5~2 μM
Incubation Time: 30 minutes
Result: Inhibited PMA-induced NF-κB p65 phosphorylation, IκBα phosphorylation and degradation and Akt phosphorylation in a concentration-dependent manner.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 0.5~2 μM
Incubation Time: 24 hours
Result: Decreased PMA-increased MUC5AC mRNA expression in a concentration-dependent manner.
Molecular Weight

1239.31

Formula

C57H90O29

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3[C@H](O)[C@](CO)(O)CO3)[C@H](O)CO2)[C@@H](O)[C@@H](O)[C@H](O[C@@H]4[C@@H](O)[C@@H](O)CO[C@H]4OC([C@]56CCC(C)(C)C[C@H]5C7=CC[C@H]8[C@](CC[C@@H]9[C@]8(C)C[C@H](O)[C@H](O[C@H]%10[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%10)[C@@]9(C(O)=O)CO)(C)[C@]7(C)C[C@H]6O)=O)O1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (20.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8069 mL 4.0345 mL 8.0690 mL
5 mM 0.1614 mL 0.8069 mL 1.6138 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.08%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8069 mL 4.0345 mL 8.0690 mL 20.1725 mL
5 mM 0.1614 mL 0.8069 mL 1.6138 mL 4.0345 mL
10 mM 0.0807 mL 0.4035 mL 0.8069 mL 2.0173 mL
15 mM 0.0538 mL 0.2690 mL 0.5379 mL 1.3448 mL
20 mM 0.0403 mL 0.2017 mL 0.4035 mL 1.0086 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Platyconic acid A
Cat. No.:
HY-N9377
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