(+)-JJ-74-138
(+)-JJ-74-138, a novel non-competitive androgen receptor (AR) antagonist, is capable of inhibiting Enzalutamide-resistant CRPC.
For research use only. We do not sell to patients.
- CAS No.: 2135545-34-3
- Formula: C22H22F8N2OS
- Molecular Weight:514.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(+)-JJ-74-138 is a potent analog of JJ-450 for the inhibition of androgen-independent AR activation in cell lines expressing AR splice variants lacking the LBD[1].
(+)-JJ-74-138 inhibits mRNA expression of AR and ARv7 target genes and reduced AR level in the nucleus in the absence of androgens[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2135545-34-3
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Molecular Weight 514.48
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Formula C22H22F8N2OS
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SMILES
O=C(N1CCN(C2=CC(C(F)(F)F)=CC=C2C)CC1)[C@H]3[C@@H](C4=CC(S(F)(F)(F)(F)F)=CC=C4)C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-JJ-74-138 Related Classifications
HY-164371 Related Classifications
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