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  3. Pparδ agonist 5

Pparδ agonist 5 

Cat. No.: HY-141494
Handling Instructions

Pparδ agonist 5, an orally active PPARδ-selective agonist (EC50=0.335 μM), is much greater than that of the prototypical standard GW0742. Pparδ agonist 5 promotes improvements in bone density and microarchitecture in vivo.

For research use only. We do not sell to patients.

Pparδ agonist 5 Chemical Structure

Pparδ agonist 5 Chemical Structure

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Description

Pparδ agonist 5, an orally active PPARδ-selective agonist (EC50=0.335 μM), is much greater than that of the prototypical standard GW0742. Pparδ agonist 5 promotes improvements in bone density and microarchitecture in vivo[1].

IC50 & Target[1] [1]

PPARδ

0.335 μM (EC50)

In Vivo

Pparδ agonist 5 (compound 31a) shows an even greater improvement in the trabecular structure, comparable to or slightly better than GW0742[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 female mice[1]
Dosage: 10 mg per kg of body weight
Administration: P.o.; per day for 6 weeks
Result: Improved the bone density at least back to normal (sham control) levels.
Molecular Weight

446.49

Formula

C₂₃H₂₁F₃N₂O₂S

SMILES

OC(/C=C/C1=CC=C(N(C)CC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)C=C1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Pparδ agonist 5Pparδ agonist5Pparδ agonist-5PPARPeroxisome proliferator-activated receptorsosteogenesismesenchymalstemcellosteoporosisInhibitorinhibitorinhibit

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Product Name:
Pparδ agonist 5
Cat. No.:
HY-141494
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