Pramipexole impurity 9
Based on 1 Customer Validation
Pramipexole impurity 9 is an impurity of Pramipexole (HY-B0410). Pramipexole is a selective Dopamine D2-type receptor agonist capable of crossing the blood-brain barrier (BBB).
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 106092-09-5
- Formula: C7H11N3S
- Molecular Weight:169.25
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].
Pramipexole (0.01-10 μM; 72 h) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 106092-09-5
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Appearance Solid
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Molecular Weight 169.25
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Formula C7H11N3S
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SMILES
NC1=NC2=C(S1)C[C@@H](N)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL (147.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78. [Content Brief]
[2]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71. [Content Brief]
[3]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961. [Content Brief]
[4]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28. [Content Brief]
[5]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.9084 mL | 29.5421 mL | 59.0842 mL | 147.7105 mL |
| 5 mM | 1.1817 mL | 5.9084 mL | 11.8168 mL | 29.5421 mL | |
| 10 mM | 0.5908 mL | 2.9542 mL | 5.9084 mL | 14.7710 mL | |
| 15 mM | 0.3939 mL | 1.9695 mL | 3.9389 mL | 9.8474 mL | |
| 20 mM | 0.2954 mL | 1.4771 mL | 2.9542 mL | 7.3855 mL | |
| 25 mM | 0.2363 mL | 1.1817 mL | 2.3634 mL | 5.9084 mL | |
| 30 mM | 0.1969 mL | 0.9847 mL | 1.9695 mL | 4.9237 mL | |
| 40 mM | 0.1477 mL | 0.7386 mL | 1.4771 mL | 3.6928 mL | |
| 50 mM | 0.1182 mL | 0.5908 mL | 1.1817 mL | 2.9542 mL | |
| 60 mM | 0.0985 mL | 0.4924 mL | 0.9847 mL | 2.4618 mL | |
| 80 mM | 0.0739 mL | 0.3693 mL | 0.7386 mL | 1.8464 mL | |
| 100 mM | 0.0591 mL | 0.2954 mL | 0.5908 mL | 1.4771 mL |
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