2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Prednimustine

Prednimustine  (Synonyms: Leo 1031; NSC 134087)

Cat. No.: HY-13732 Purity: 95.58%
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Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.

For research use only. We do not sell to patients.

Prednimustine

Prednimustine Chemical Structure

CAS No. : 29069-24-7

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Based on 1 publication(s) in Google Scholar

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Description

Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research[1].

In Vivo

Prednimustine (120 mg/kg; s.c.; single dose) shows much less toxic than equimolar doses of Chlorambucil.html" class="link-product" target="_blank">Chlorambucil (HY-13593) (60 mg/kg; s.c.; single dose) in non-tumour-bearing rat model, due to differences in alkylating agent pharmacokinetics[1].
Prednimustine (40 mg/kg; s.c.; single dose) produces low plasma concentrations (less than 5 microM) of the alkylating metabolites chlorambucil and phenyl acetic mustard, which were maintained for 48 h in rats bearing the sensitive strain of the Walker 256 carcinosarcoma grown as an ascites[1].
Prednimustine (40 mg/kg;s.c.; single dose; measured at 72 h) shows antitumor effect in rats model with the alkylating agent-resistant strain of the Yoshida sarcoma[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats non-tumour-bearing (150-200g)[1]
Dosage: 120 mg/kg
Administration: Subcutaneous injection; single dose; observed at day 21
Result: Remained 100% survival of rats, while 0% survival for Chlorambucil treatment group.
Animal Model: Female Wistar rats bearing the alkylating agent-resistant strain of the Yoshida sarcoma (150-200g)[1]
Dosage: 40 mg/kg
Administration: Subcutaneous injection; single dose
Result: Killed 57% of the resistant tumour cells.
Clinical Trial
Molecular Weight

646.64

Formula

C35H45Cl2NO6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

C[C@@]12[C@](C(COC(CCCC3=CC=C(N(CCCl)CCCl)C=C3)=O)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (154.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5465 mL 7.7323 mL 15.4646 mL
5 mM 0.3093 mL 1.5465 mL 3.0929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5465 mL 7.7323 mL 15.4646 mL 38.6614 mL
5 mM 0.3093 mL 1.5465 mL 3.0929 mL 7.7323 mL
10 mM 0.1546 mL 0.7732 mL 1.5465 mL 3.8661 mL
15 mM 0.1031 mL 0.5155 mL 1.0310 mL 2.5774 mL
20 mM 0.0773 mL 0.3866 mL 0.7732 mL 1.9331 mL
25 mM 0.0619 mL 0.3093 mL 0.6186 mL 1.5465 mL
30 mM 0.0515 mL 0.2577 mL 0.5155 mL 1.2887 mL
40 mM 0.0387 mL 0.1933 mL 0.3866 mL 0.9665 mL
50 mM 0.0309 mL 0.1546 mL 0.3093 mL 0.7732 mL
60 mM 0.0258 mL 0.1289 mL 0.2577 mL 0.6444 mL
80 mM 0.0193 mL 0.0967 mL 0.1933 mL 0.4833 mL
100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3866 mL
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Prednimustine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Prednimustine29069-24-7Leo 1031 NSC 134087Leo1031Leo-1031NSC134087NSC 134087NSC-134087DNA Alkylator/Crosslinkeralkylating agent-resistant strainYoshida sarcomasensitive strainWalker 256 carcinosarcomaascitesleukemiaslymphomasInhibitorinhibitorinhibit

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