AURKA/AurA
Aurora A kinase, encoded by AURKA, is a serine/threonine kinase that concentrates at centrosomes and spindle poles from late G2 through mitosis. Activated by binding of the cofactor TPX2, it drives centrosome maturation, mitotic entry and bipolar spindle assembly, phosphorylating substrates that include PLK1 and components of the microtubule machinery. AURKA amplification and overexpression occur in many cancers and are associated with chromosomal instability, and the kinase is also implicated in ciliary resorption. Aurora A is a validated drug target, with inhibitors such as alisertib evaluated clinically in hematologic and solid tumors.
-
AURKA/AurA Recombinant Proteins (3)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
