CD200R4
CD200R4 (also CD200R-like 4, within the CD200R1L cluster) is one of the activating-type members of the CD200 receptor family in rodents. CD200R4 is a type I transmembrane Ig superfamily protein whose ectodomain shows the family-typical V-set/C2-set domain organization, while its transmembrane region contains a charged lysine residue that permits association with the adaptor protein DAP12 (TYROBP), enabling activating immunoreceptor signaling via SYK and ZAP70 kinases. CD200R4 is expressed on myeloid populations, including dendritic cell and macrophage subsets, and participates in cellular activation during antimicrobial and allergic immune responses. Similar to CD200R3 on basophils and mast cells, CD200R4 couples to DAP12 and amplifies inflammatory mediator release, contrasting with the inhibitory CD200R1 that recruits Dok-RasGAP modules. The activating members of this family illustrate that the CD200-CD200R system is not monolithically tolerogenic but instead comprises a balanced set of inhibitory and activating receptors that fine-tune myeloid cell responses.
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CD200R4 Recombinant Proteins (2)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
