CDK11A/CDC2L2
CDK11A lies beside its paralog CDK11B on chromosome 1p36 and encodes PITSLRE-family kinases, historically called CDC2L2. These kinases pair with cyclin L isoforms to regulate transcription, pre-mRNA splicing and sister chromatid cohesion. CDK11 exists as p110 and p58 forms; p58 is generated by caspase cleavage or IRES-driven translation during apoptosis and promotes cell death, linking CDK11A to apoptotic signaling as well as cell-cycle control. CDK11A is widely expressed and has roles in autophagy and in cancer cell survival; CDK11 inhibitors are being explored in melanoma and multiple myeloma, contexts where the kinase is overactive.
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CDK11A/CDC2L2 Recombinant Proteins (2)
- Species:
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
