CDK20/CCRK
Unusually among CDKs, CDK20 — also called CCRK, the cell cycle-related kinase — is fully active as a monomer and does not require a cyclin partner. It functions upstream in the CDK cascade by phosphorylating the activation loop of CDK7, thereby boosting CAK activity and indirectly driving CDK1/CDK2-dependent cell-cycle entry. CDK20 is expressed in proliferating tissues such as brain, testis and intestine and is overexpressed in several cancers, where it correlates with poor prognosis. Its cyclin-independent design makes CDK20 a distinct node among CMGC kinases and a potential target where CAK output must be suppressed.
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CDK20/CCRK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
