ERK4/MAPK4
ERK4 (MAPK4) is the close paralog of ERK3 and shares its unusual design: a single SEG-type phosphorylation site rather than a TEY motif, constitutive phosphorylation in cells, an extended C-terminal region, and rapid turnover through the ubiquitin-proteasome system. It binds and activates MAPK-activated protein kinase 5 in the same manner as ERK3, and the two kinases have overlapping but not identical expression patterns and roles in cell migration, cytoskeletal organization, and stress responses. Because ERK4 lacks classical upstream MAP2K regulation, it remains less characterized than the ERK1/2 pair. Recombinant ERK4 supports studies of MK5 signaling and of atypical-MAPK inhibitor selectivity.
-
ERK4/MAPK4 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
