FGF-18
FGF-18 is a cartilage- and bone-centric ligand that signals through FGFR3 as well as FGFR1 and FGFR2. It drives proliferation of growth-plate chondrocytes, osteoblast differentiation and skull and limb skeletal development; Fgf18-null mice display delayed ossification and cleft palate. In adults FGF-18 is expressed in cartilage, lung and liver, and it stimulates proteoglycan synthesis in articular chondrocytes. A recombinant human FGF-18 variant, sprifermin, has been evaluated in clinical trials for knee osteoarthritis, where intra-articular injection increased cartilage thickness. Recombinant FGF-18 is used in chondrogenesis assays, skeletal biology research and FGFR3 ligand studies.
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FGF-18 Recombinant Proteins (6)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
