GRK2/BARK1
GRK2, originally isolated as beta-adrenergic receptor kinase 1 (BARK1), is the prototype of the BARK subfamily and among the most abundant GRKs in cells. Its domain organisation combines an N-terminal regulator of G protein signalling homology domain that binds activated Gαq, a central kinase domain and a C-terminal pleckstrin homology domain that docks Gβγ and clathrin to bring the enzyme to activated receptors at the membrane. GRK2 desensitises beta-adrenergic, muscarinic, opioid and chemokine receptors and also acts away from the membrane on partners such as PI3Kgamma and tubulin. Cardiac GRK2 levels rise in heart failure, making it a therapeutic target.
-
GRK2/BARK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
