Integrin alpha 6 beta 1
Integrin alpha 6 beta 1 is a major laminin receptor of the beta-1 class, formed by CD49f and CD29. Unlike its hemidesmosomal counterpart alpha 6 beta 4, it localizes to focal adhesions and supports dynamic adhesion, spreading and migration on laminin-111, laminin-511 and related isoforms. It is prominent on endothelial cells during angiogenesis, on Schwann cells and neurons that interact with laminin in basement membranes, and on epithelial and hematopoietic stem and progenitor cells. Antibody-defined epitopes of alpha 6 beta 1 have long been used to isolate stem cell populations, and the receptor contributes to tumor invasion and to vascular development in the retina.
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Integrin alpha 6 beta 1 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
