Integrin alpha M beta 2
Integrin alpha M beta 2, better known as Mac-1, CR3 or CD11b/CD18, is the most abundant beta-2 integrin on myeloid cells including monocytes, macrophages, neutrophils and NK cells. Its alpha M I-domain binds a remarkably diverse ligand set: the complement opsonin iC3b, fibrinogen, ICAM-1, heparin and denatured proteins, enabling phagocytosis of opsonized microbes, adhesion to endothelium, and signaling for degranulation and respiratory burst in neutrophils. CD11b is a standard activation marker measured on granulocytes by flow cytometry. Mac-1 also mediates leukocyte recruitment in thrombosis and ischemia-reperfusion injury, and blocking antibodies remain key research tools for dissecting complement-dependent phagocytosis and myeloid cell adhesion.
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Integrin alpha M beta 2 Protéines Recombinantes (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formule: Human
- Masse moléculaire: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
