IRE2/ERN2
IRE2β (ERN2), the paralog of the ubiquitously expressed IRE1α, shows a restricted expression pattern concentrated in secretory epithelia of the gut, airway and liver. Like IRE1α, it is an ER transmembrane protein with luminal sensing, kinase and RNase domains that respond to unfolded protein load and can splice XBP1 mRNA and perform RIDD, though generally with lower activity. IRE2β has been implicated in tuning mucosal secretory function, intestinal inflammation and host responses to infection, and it helps shape ER homeostasis in cells with high secretory demand. Recombinant IRE2β supports comparative studies of the two IRE1 branches of the unfolded protein response.
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IRE2/ERN2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
