ITIH3
ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3) is a liver-secreted plasma glycoprotein of the inter-alpha-trypsin inhibitor (ITI) family. Heavy chains such as ITIH3 are covalently attached, via chondroitin sulfate, to bikunin to form the circulating ITI complexes that stabilize hyaluronan-rich extracellular matrix and restrain inflammatory proteolysis at sites of tissue injury. ITIH3 contains an N-terminal VIT domain characteristic of the family and behaves as an acute-phase reactant. Genetic variants near ITIH3 have been associated with rheumatoid arthritis susceptibility, and altered serum levels are reported in cancers and inflammatory diseases, supporting its biomarker candidacy. Recombinant ITIH3 aids studies of ITI assembly and inflammation.
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ITIH3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
