MAP3K5/ASK1
MAP3K5, universally known as ASK1 (apoptosis signal-regulating kinase 1), is a central STE11-group MAP3K of oxidative and endoplasmic reticulum stress signaling. In resting cells ASK1 is held inactive by reduced thioredoxin bound to its N-terminal region; ROS-dependent oxidation releases this brake, permitting oligomerization with TRAF2 and autophosphorylation. Active ASK1 phosphorylates MKK4/7 and MKK3/6, driving sustained JNK and p38 activation that culminates in apoptosis. ASK1 contributes to neurodegeneration, cardiac hypertrophy, diabetes and inflammatory diseases, and its inhibitor selonsertib reached late-stage clinical trials in NASH, making ASK1 a flagship drug target among MAP3Ks.
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MAP3K5/ASK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
