MKNK2/MNK2
MKNK2, MAPK-interacting kinase 2 or MNK2, partners with MNK1 in phosphorylating eukaryotic initiation factor 4E at serine 209. It differs fundamentally in regulation, showing substantially higher basal kinase activity than MNK1 and less dependence on ERK and p38 activation-loop phosphorylation. MNK2-mediated phosphorylation of the cap-binding factor promotes translation of messenger RNAs driving oncogenesis, and combined Mnk1 and Mnk2 deletion attenuates tumor formation in mouse cancer models, implicating the pathway in malignant progression. Dual MNK inhibitors such as tomivosertib have entered clinical trials in oncology, exploiting the dispensability of MNK signaling in normal adult tissues while targeting translation of pro-tumor transcripts.
-
MKNK2/MNK2 Recombinant Proteins (2)
- Species:
- Source:
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
