p38b/MAPK11
p38β (MAPK11, SAPK2) is the second most abundant p38 isoform and is widely but modestly expressed relative to p38α. It is activated by MKK3 and MKK6 through phosphorylation of its Thr-Gly-Tyr motif and shares the core substrate set of the family, including MK2, MK3, and ATF2, which makes it largely redundant with p38α in many stress and inflammatory responses. Differences emerge in proliferation, angiogenesis, and certain cell-cycle functions, and p38β is inhibited by SB203580, unlike p38γ and p38δ. Overexpression has been reported in some tumors. Recombinant p38β is used to quantify isoform contribution and selectivity in p38-directed drug discovery.
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p38b/MAPK11 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
