PRKG2/PKG2
Type II cGMP-dependent protein kinase, encoded by PRKG2, is distinguished from PKG1 by an N-terminal myristoylation signal that anchors it to the plasma membrane. It is expressed most highly in intestine, kidney, growth plate cartilage and brain, and mediates C-type natriuretic peptide and NO-cGMP signals controlling chloride secretion, chondrocyte proliferation and bone growth; Prkg2-deficient mice are dwarfed through disrupted endochondral ossification. PKG2 also modulates neuronal excitability and circadian behavior. Recombinant PKG2 enables comparison of membrane-tethered versus cytosolic cGMP kinase signaling and studies of the CNP-PKG2 axis in skeletal development and intestinal ion transport.
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PRKG2/PKG2 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
