PTP alpha
PTP alpha (PTPRA) is a classical receptor-type protein tyrosine phosphatase with a single transmembrane segment, a compact extracellular region containing a MAM-like module, and two tandem intracellular catalytic domains. The membrane-proximal D1 domain provides the dominant activity and binds substrates including the C-terminal inhibitory tyrosine of Src family kinases, positioning PTP alpha as a positive regulator of Src and Fyn signaling. Through this axis it influences integrin signaling, insulin responses, cell proliferation, and neuronal development. PTP alpha also associates with GRB2 and has been implicated in tumorigenesis, where increased expression sustains Src-dependent transformation. Recombinant forms are used to dissect domain-specific phosphatase mechanisms.
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PTP alpha Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
