New lead compounds for brassinosteroid biosynthesis inhibitors

  • Bioorg Med Chem Lett. 1999 Feb 8;9(3):425-30. doi: 10.1016/s0960-894x(99)00008-6.
Y K Min  1 ,  T Asami ,  S Fujioka ,  N Murofushi ,  I Yamaguchi ,  S Yoshida
Affiliations
  • 1. The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan.
PMID: 10091696 DOI: 10.1016/s0960-894x(99)00008-6
Abstract

The first brassinosteroid biosynthesis inhibitor is reported. Among newly synthesized triazole derivatives, 4-(4-chlorophenyl)-2-phenyl-3-(1,2,4-triazoyl)butan-2-ol (6) was found to inhibit the growth of cress seedlings, and this inhibition was recovered by the treatment of Brassinolide, suggesting that compound 6 primarily inhibits brassinosteroid biosynthesis.

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