Anti-AIDS agents part 41: synthesis and anti-HIV activity of 3',4'-di-o-(-)-camphanoyl-(+)-cis-khellactone (DCK) lactam analogues

  • Bioorg Med Chem Lett. 2000 May 15;10(10):1003-5. doi: 10.1016/s0960-894x(00)00126-8.
Z Y Yang  1 ,  Y Xia ,  P Xia ,  A Brossi ,  L M Cosentino ,  K H Lee
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
PMID: 10843202 DOI: 10.1016/s0960-894x(00)00126-8
Abstract

DCK lactam analogues were synthesized and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 4-Methyl-DCK lactam (11a) exhibited potent anti-HIV activity with EC50 and therapeutic index values of 0.00024 microM and 119,333, respectively.