Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine

  • Immunopharmacol Immunotoxicol. 2000 May;22(2):253-66. doi: 10.3109/08923970009016419.
H M Kim  1 ,  N H An ,  B H Yi ,  H J Chae ,  H R Kim ,  S J Moon ,  J J Kim ,  S T Park ,  S H Baek
Affiliations
  • 1. College of Pharmacy, Professional Graduate School of Oriental Medicine, Center of Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. [email protected]
PMID: 10952030 DOI: 10.3109/08923970009016419
Abstract

We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 microg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.

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