Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus

  • J Antibiot (Tokyo). 2000 Nov;53(11):1265-71. doi: 10.7164/antibiotics.53.1265.
S Sakuda  1 ,  M Ono ,  H Ikeda ,  T Nakamura ,  Y Inagaki ,  R Kawachi ,  J Nakayama ,  A Suzuki ,  A Isogai ,  H Nagasawa
Affiliations
  • 1. Department of Applied Biological Chemistry, The University of Tokyo, Japan.
PMID: 11213287 DOI: 10.7164/antibiotics.53.1265
Abstract

Blasticidin A, an Antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM.

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