LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

  • Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. doi: 10.1016/s0960-894x(01)00099-3.
G Chiosis  1 ,  N Rosen ,  L Sepp-Lorenzino
Affiliations
  • 1. Department of Molecular Oncogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. [email protected]
PMID: 11294389 DOI: 10.1016/s0960-894x(01)00099-3
Abstract

Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of HSP90 and thereby creating selective inhibitors of PI3K and PI3K-related family.